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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 ______________________
FORM 8-K
CURRENT REPORT
Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

Date of Report (Date of earliest event reported) August 11, 2014

RETROPHIN, INC.
(Exact name of registrant as specified in its charter)

Delaware		001-36257	27-4842691
(State or other jurisdiction of incorporation)		(Commission File Number)	(I.R.S. Employer Identification No.)

777 Third Avenue, 22nd Floor, New York, NY			10017
(Address of principal executive offices)			(Zip Code)

Registrant’s telephone number, including area code (646) 837-5863


(Former name or former address, if changed since last report.)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

¨	Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
¨	Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
¨	Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
¨	Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13a-4(c))

Item 8.01 Other Events.

On August 11, 2014, Retrophin, Inc. (the “Company”) announced that a second Pantothenate kinase-associated neurodegeneration (“PKAN”) patient began dosing with RE-024 under a physician-initiated research protocol. The subject received the first dose of RE-024 on July 24, 2014. Soon after initiating RE-024, the treating physician reported qualitative clinical improvement in the subject’s motor exam, including speech, facial expression, and finger-tapping. The subject remains on a stable dose of RE-024. Preliminary clinical data from this subject are shown in Table 1 below. Further data points, including biochemical analysis, are pending at this time.

The first subject who began dosing under a physician-initiated protocol on May 21, 2014 remains on a stable dose of RE-024. The subject is clinically stable and has demonstrated sustained clinical improvement from baseline. The subject’s liver function tests remain normal after a temporary elevation, and the subject’s lactate levels, which were elevated at baseline, have decreased to normal levels. Clinical data from this subject are summarized in Table 1, and biochemical data are shown in Table 2.

The Company does not believe data on a small number of patients can be interpreted in a robust fashion and is releasing this data to accommodate investor requests. Further, the results are inconclusive at this time with regard to RE-024’s ability to treat patients that suffer from PKAN. Potential investors should not place undue reliance on these early data points.

TABLE 1: Clinical data summary (as of August 11, 2014)

Week 0

Week 1

Week 2

Week 3

Week 4

Week 5

Week 7

Week 11

SUBJECT 1

UPDRS1 (A+B+C)

74/118

56/118

63/118

58/118

56/118

48/118

50/118

Subscale A

8/10

3/10

4/10

3/10

2/10

3/10

Subscale B

36/52

26/52

27/52

26/52

23/52

22/52

Subscale C

30/56

27/56

33/56

28/56

27/56

23/56

25/56

BADS2

14/24

15/24

14/24

16/24

13/24

14/24

13/24

14/24

EQ-5D-3L

12/15

10/15

9/15

8/15

10/15

25 foot walk test

# of steps

25.5

19.5

17.0

16.0

16.5

15.0

14.0

14.5

Time in seconds

10.5

11.3

8.6

11.1

8.9

8.2

7.6

7.8

SUBJECT 2

Week 0

Week 13

UPDRS (A+B+C)

53/118

36/118

Subscale A

4/10

Subscale B

23/52

17/52

Subscale C

26/56

15/56

BADS

14/24

13/24

TABLE 2: Biochemical data summary (as of August 11, 2014)

	Week 0		Week 1		Week 2		Week 3		Week 4		Week 5		Week 7		Week 11
SUBJECT 1
ALT		34		31		85		65		38		35		27	WNL4
AST		26		23		55		32		29		30		26	WNL
Lactate		2.44		1.42		1.46		1.29		1.69		1.07		1.28

_______________

1 Unified Parkinson’s Disease Rating Scale

2 Barry-Albright Dystonia Scale

3 Subject 2 Week one measurements were obtained on August 5, 2014

4 Within Normal Limits per physician report

ABOUT PKAN

Pantothenate kinase-associated neurodegeneration or PKAN is the most common form of neurodegeneration with brain iron accumulation. Classic PKAN is a genetic disorder that is typically diagnosed in the first decade of life. Consequences of PKAN include dystonia, dysarthria, rigidity, retinal degeneration, and severe digestive problems. PKAN is estimated to affect 1 to 3 persons per million. PKAN typically manifests in childhood with a profound, progressive dystonia and is usually lethal. There are currently no viable treatment options for patients with PKAN.

ABOUT RE-024

RE-024 is a phosphopantothenate prodrug replacement therapy with the goal of restoring the supply of this operative substrate in PKAN patients. The results discussed in this Current Report on Form 8-K relate to the first two PKAN patients who have initiated treatment with RE-024 and are not indicative of future responses by these patients or by other patients.

SIGNATURE

Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

	RETROPHIN, INC.

Date: August 11, 2014	By:	/s/ Marc Panoff
		Name: Marc Panoff Title: Chief Financial Officer